June Edition: The Longevity Report

June Edition: The Longevity Report

Welcome to The Longevity Report — our monthly newsletter dedicated to empowering your health journey through education, science, and real results.

Each issue will bring you practical insights into the therapies, technologies, and patient stories that define our mission: to help you live stronger, heal faster, and feel your best for years to come.

June 2025 Newsletter: Cardiovascular Diagnostics & Regenerative Prevention

Cardiovascular Health: A New Era of Precision Prevention

Your heart beats over 100,000 times a day — and yet, many people don't give it a second thought until symptoms strike. But by then, damage is often already done.

At Longevity Medical Institute (LMI), we're rewriting the cardiovascular story. Through proactive diagnostics and regenerative cellular therapies unavailable in the U.S. or Canada, we offer a level of care that moves beyond symptom management. Our IV-delivered stem cell and exosome treatments - including targeted peptides and  nutraceuticals that work at the cellular level to support and repair the cardiovascular system from the inside out.

The Result? Patients not only reduce their risk of heart disease, but also enhance vascular function for greater energy, mental clarity, and resilience at every stage of life.

Research Insight: Did you know that up to 45% of patients referred for invasive coronary angiography are found to have no obstructive Coronary Artery Disease (CAD)? This staggering statistic underscores the urgent need for more accurate, non-invasive risk assessment tools. At Longevity Medical Institute, we're addressing this gap by offering precision evaluation without unnecessary risk.

DIAGNOSTIC SPOTLIGHT: CADScor® – A First in Mexico and Available Exclusively at Longevity Medical Institute

CADScor® won the Global Cardiovascular Digital Innovation Award! And is a first-of-its-kind device that uses acoustic AI technology to detect early-stage coronary artery disease (CAD) in less than 10 minutes — without radiation, blood draws, or imaging. LMI is the exclusive provider of CADScor® in the Los Cabos market, making us the only clinic in the region offering this world-class diagnostic innovation.

How it works:

• A specialized microphone captures cardiac acoustic signals, including coronary turbulence and microvascular flow changes, for both hard and soft plaque.
• These signals are analyzed using a machine learning algorithm trained on tens of thousands of patient cases.
• A personalized CAD-score is generated, stratifying your risk level in real time.

Clinical Advantages:

1. 96% Negative Predictive Value (NPV) for ruling out CAD
2. No radiation, no contrast, no stress testing
3. Helps avoid unnecessary CT angiography and invasive diagnostics
4. Completed in under 10 minutes during your routine visit
5. Validated in multicenter trials and now FDA-cleared

This is proactive heart care — accessible, accurate, and patient-friendly. And it's only at LMI.

Just Added in June! AI is Again at the Heart of Our Care at LMI With Even More Advanced Cardiac Detection Methods

This month, we're proud to announce the integration of our Eko CORE 500 digital stethoscopes with the AI-powered SENSORA™ Platform - another revolutionary step forward in cardiovascular diagnostics at LMI.

Unlike traditional stethoscopes, the Eko CORE 500 features high-fidelity audio, real-time ECG capabilities, and a full-color digital display. When paired with SENSORA™, this device uses artificial intelligence to analyze heart sounds and ECG waveforms instantly, flagging critical indicators like:

1. Low Ejection Fraction: Detects reduced heart pumping ability, a hallmark of heart failure
2. Structural Murmurs: Flags valvular abnormalities that often go unnoticed during routine exams
3. Atrial Fibrillation: Identifies abnormal heart rhythms linked to stroke and cardiovascular risk

Clinically Proven. Validated by Data.

The clinical performance behind this combined technology is robust and well-validated. SENSORA's algorithms were trained on over 100,000 ECGs and 1 million heart sound recordings, and have demonstrated up to 98% sensitivity for murmur detection and 85% sensitivity for low EF in real-world studies. By combining Eko's stethoscope innovation with AI, we're transforming every patient encounter into an opportunity for earlier intervention, better outcomes, and longer lives.

Do You Still Need a Traditional EKG if You Have the Eko CORE 500 + SENSORA?

Yes, because together they're even more powerful!

Longevity Medical Institute also utilizes a state-of-the-art 12-lead EKG system to provide an even deeper, more detailed view of cardiac health. Why? Because we want to get to the heart of the matter - no pun intended.

The 12-lead EKG complements our real-time screening tools by giving us a broader electrical map of the heart, allowing for more comprehensive diagnostic clarity when needed.

• Identifies complex arrhythmias and conduction abnormalities not captured by 3-lead systems
• Assesses heart chamber enlargement, axis deviations, and waveform anomalies
• Detects early signs of ischemia or other subtle electrical disturbances
• Complements AI diagnostics by confirming or expanding on preliminary findings from SENSORA™

Our advanced diagnostic tools allow us to blend precision technology with clinical insight, delivering the most complete cardiac assessments available in proactive, personalized care.

CARDIOVASCULAR FUNCTION BLOOD PANEL: In-House Lab Panel

LMI's cardiovascular assessment panel goes far beyond standard cholesterol testing. Our in-house clinical lab evaluates both structural and inflammatory risk, enabling precise therapeutic targeting.

As part of our comprehensive 70-biomarker panel, we measure:

• Total cholesterol, HDL, LDL, VLDL, and triglycerides

• Apo B, Apo A1, Apo B:A1 ratio

• Atherogenic index

• High-Sensitivity CRP (hs-CRP) — a key marker for vascular inflammation

• NT-proBNP — a predictor of early cardiac fatigue or dysfunction

• Homocysteine — linked to arterial inflammation and stroke risk

• Lipoprotein(a), sdLDL particle size (when indicated)

• Insulin, glucose, HbA1c, and HOMA-IR — evaluating metabolic contributors to cardiovascular disease

What Patients Are Saying

Michael Elliot - award-winning Hollywood screenwriter and producer visited Longevity Medical Institute while vacationing in Cabo San Lucas. What started as a friendly tour ended with a complimentary cardiac evaluation … revealing a serious heart issue that required immediate follow-up with a cardiologist. Had he not caught it, the outcome could've been tragic.

LISTEN TO HIS POWERFUL MESSAGE

“Making your heart’s healthy is critical self-care. I encourage everyone to make heart-focused diagnostic testing a priority, a routine, and a lifestyle.” - Michael Elliot

Amazing, right?

The level of non-invasive insight we can now gain into your cardiovascular health - often in just minutes - is truly transformative. But diagnostics are just the beginning.

The next question is: What can you do about it?

At Longevity Medical Institute, we don't just stop at detection. We go further by offering intravenous regenerative therapies for cardiovascular repair that you simply won't find in standard U.S. or Canadian clinics.

These advanced treatments are designed to not only support heart function but also promote cellular healing, reduce inflammation, and improve overall vascular integrity:

Placental Stem Cells & Exosomes (IV) Made in our ISO-certified Biotechnology Lab

Delivered intravenously, our placental MSCs and purified exosome protocols directly support:

• Endothelial repair at the capillary and arterial level
• Vascular inflammation suppression by modulating immune cytokines
• Angiogenesis, encouraging the growth of new blood vessels in oxygen-deprived tissue
• Mitochondrial rejuvenation, enhancing ATP production in cardiac muscle
• Nitric oxide signaling, improving blood flow and pressure regulation

LMI's cell-derived therapies are systemically active and naturally home to areas of vascular injury via chemotactic signaling. This makes them highly effective for patients with early hypertension, vascular stiffness, microvascular angina, or post-COVID endothelial dysfunction.

TB-500 and Cardiovascular Peptides

TB-500 is a regenerative peptide that promotes cardiac healing, reduces scar formation, and improves microcirculatory integrity. It works by upregulating actin-binding proteins involved in angiogenesis and cellular migration.

Other cardiovascular-supportive peptides in use at LMI include:

• GHK-Cu: Promotes arterial elasticity and collagen synthesis
• BPC-157: Reduces endothelial inflammation and supports arterial repair
• Epitalon: Supports telomere stabilization in endothelial cells and cardiac tissue

IV NUTRACEUTICAL THERAPY FOR HEART HEALTH

All of our nutraceuticals are custom-formulated and administered intravenously, allowing for maximum therapeutic absorption, mitochondrial support, and anti-inflammatory benefits — especially where cardiovascular optimization is the goal.

Each formulation is designed to reduce vascular inflammation, improve endothelial function, boost energy metabolism, and support detoxification and recovery.

HYPERBARIC OXYGEN THERAPY (HBOT): Vascular Repair at the Cellular Level

Hyperbaric Oxygen Therapy is one of the most potent tools in regenerative cardiovascular medicine. At LMI, we use HBOT's to stimulate tissue oxygenation, reverse hypoxia, and activate cellular repair across the vascular system.

Cardiovascular Benefits:

• Stimulates angiogenesis and capillary perfusion
• Enhances nitric oxide production and mitochondrial ATP output
• Reduces systemic inflammation and oxidative stress
• Mobilizes endothelial progenitor cells (EPCs) for vascular repair

HBOT is particularly effective when combined with IV exosome or stem cell protocols, further amplifying regenerative outcomes.

WHAT TO DO THIS MONTH

• Get your CADScor® scan - only at LMI
• Get your EKO + Sensora Evaluation
• Schedule your Cardiovascular Optimization Panel + EKG
• Begin your IV stem cell and exosome therapy
• Add TB-500 and other peptides to your vascular protocol
• Start your IV Detox, Boost, or Recovery infusions
• Book your HBOT and Recharge Station sessions
• Review your statin use with an LMI provider